Primary enuresis affects an estimated five million to seven million American children and teen-agers.
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Jellinek said, " in the last decade clinicians have suspected that primary enuresis was inherited.
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In persistent bed-wetting, or primary enuresis, children 7 or older wet the bed three or more times a week.
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Eiberg screened 400 families to find 11 in which one parent and at least one child both had histories of primary enuresis.
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Previous studies of primary enuresis with larger numbers of families estimated that if both parents were affected, about two-thirds of their children would inherit the problem.
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In their report, the researchers said a gene for primary enuresis was on the long arm of chromosome 13 of the 23 pairs of chromosomes in human cells.
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Desmopressin, a synthetic analogue of the hormone vasopressin, which regulates urine production, has been found most effective in children with primary enuresis, and less so with those children who wet the bed only occasionally.
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He also cautioned that the gene for primary enuresis " may be part of a bigger behavioral syndrome, " noting that " for most human behavior there is not just one gene, but multiple ones interacting ."
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